Biginelli Reaction and ?-Secretase Inhibition: A Multicomponent Reaction as a Friendly Educational Approach to Bioactive Compounds

Multicomponent reactions (MCRs) represent very interesting tools to reach eco-friendly and sustainable transformations in organic chemistry. In particular, the Biginelli reaction furnishes a easy approach synthesis of library biological active compounds an academic course. Here we describe realization several experiments involving potential inhibitors ?-secretase by reaction. All obtained were tested with FRET fluorimetric assay. The proposed students either at entry level or during advanced laboratory courses bioorganic learning objectives introduce practice combinatorial evaluation activity libraries enzyme inhibition assays. meeting was probed first analyzing their daily performance increasing proactive attitude, contents final presentations. resulting marks compared average career. Second, asked evaluate course own experience, outcome that teachers.